Pluronic F-127 gel

Pluronic F-127 gel is a polaxamer with useful as well as interesting physical characteristics. It is usually used in the 20% strength.

When it is chilled, it becomes liquid, but it hardens when warmed. Opposite of what should be expected. This characteristic makes it useful in pharmaceutical compounding because it can be drawn into a syringe for accurate dose measurement when it is cold. When it warms to body temperature (when applied to skin) it thickens to a perfect consistency (especially when combined with soy lecithin/isopropyl palmitate) to facilitate proper inunction and adhesion.

When chilled, the gel has a pharmaceutically elegant consistency, is odorless, colorless, and non-greasy. When applied to the skin, it thickens rapidly then penetrates and dries leaving a small amount of residue that is not uncomfortable.

Miscellaneous Factors:

DMSO and lecithin/isopropyl palmitate help increase absorption through the skin and significantly improve the performance of Pluronic F-127 gel. Several other factors may influence the percutaneous absorption of medicaments: the site of application, the length of time such application remains in contact with the skin, the amount of inunction used in applying the medicated application, and skin temperature. Drugs which penetrate the stratum corneum do so most readily where the outer keratic layer is thin.

Acology Prescription Compounding Center - (http://www.Rx4u.com)